Synthesis, Characterization and Biological Studies of Metal Complexes Derived from 3–Hydroxyquinoxaline–2–Carboxaldehyde and 2–Aminobenzothiazole
P. Dharmapandian1, J. Joseph2, J. Dharmaraja3
1Dr. P. Dharmapandian, Associate Professor & Head, Department of Chemistry, Marthandam College of Engineering and Technology, Kuttakuzhi, Veeyannoor, Kanyakumari District, Tamil Nadu, India.
2Dr. J. Joseph, Associate Professor, Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, Tamil Nadu, India.
3Dr. J. Dharmaraja, Associate Professor & Head, Department of Chemistry, Sree Sowdambika College of Engineering, Aruppukottai, Virudhunagar District, Tamil Nadu, India.
Manuscript received on December 02, 2018. | Revised Manuscript received on December 15, 2018. | Manuscript published on December 30, 2018. | PP: 10-14 | Volume-5 Issue-11, December 2018. | Retrieval Number: K12881151118
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© The Authors. Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Novel metal complexes were synthesized by the condensation of 3–hydroxyquinoxaline–2–carboxaldehyde and 2–aminobenzothiazole. Using elemental analysis, IR, 1H–NMR, UV–Vis., molar conductance, magnetic moment and electrochemical studies, the ligands and its metal complexes were characterized. The magnetic moment and electronic spectral data evidenced that all the complexes exhibit square planar geometry. The metal complexes showed better antimicrobial screening than that of its free ligands. Using the cyclic voltammetry technique, the DNA binding behavior of complexes with CT DNA has been studied. The DNA binding constants revealed that intercalation binding mode for all metal complexes with DNA. Antibacterial screening of the ligand and its complexes reveal that all the complexes show higher activities than the ligand.
Keywords: 2-Aminobenzothiazole; Metal–Schiff base Complexes; Spectral; DNA binding; Antimicrobial; Antioxidant activities.